Grant Information

CAP: THERAPEUTIC MOLECULE EVALUATION AND FIELD DELIVERY PIPELINE FOR SOLUTIONS TO HLB

Sponsoring Institution Agricultural Research Service/USDA
Status ACTIVE
Funding Source USDA COOPERATIVE AGREEMENT
Reporting Frequency Annual
Project Director SHATTERS R G
Accession Number 438915
Project Number 6034-22320-007-016A
Dates 2020-10-01 - 2025-07-31
Recipient Organization Indian River State College
3209 Virginia Avenue
Fort Pierce,FL 34981
Keywords asiaticus
candidatus
citrus
clas
greening
hlb
huanglongbing
liberibacter
therapeutics
Research Effort Applied (30%)
Basic (45%)
Developmental (25%)
Classification Parameters
Knowledge AreaSubject of InvestigationField of SciencePercent
211 - Insects, Mites, and Other Arthropods Affecting Plants 910 - Grapefruit 1040 - Molecular biology 40%
215 - Biological Control of Pests Affecting Plants 920 - Orange 1130 - Entomology and acarology 40%
211 - Insects, Mites, and Other Arthropods Affecting Plants 1131 - Wine grapes 1130 - Entomology and acarology 10%
216 - Integrated Pest Management Systems 1130 - Table grapes 1040 - Molecular biology 10%
Goals / Objectives
Funds provided to cooperator are to support the following objectives fulfilling the educational outreach component of the grant: IRSC will provide students at Indian River State College (IRSC) training and research experience in synthetic biology, microbiology, molecular biology and to explore how these disciplines are used in agriculture.
Methods (unparsed)

At Indian River State College (IRSC), two laboratory modules will be developed for a biotechnology lab that will introduce students to plant transformations using the Agrobacterium model system and Ribonucleic acid interference (RNAi). The labs module will be developed by jointly IRSC faculty and researchers at the USDA. The Agrobacterium module will use transgenic expression of a fluorescent protein in transformed PHACT-biofactories to introduce students to this transgenic system. The module is adaptable to allow for additional instruction of the expression system by Poly chain reaction (PCR), quantitative Poly chain reaction (qPCR), protein analysis and microscopy. The RNAi module will use bioinformatics to introduce students to dsRNA design and the students can test their double-stranded Ribonucleic acid (dsRNAs) for activity as part of the assay pipeline described in Obj. 2. The biotechnology course is offered each fall and spring semester, with sections of 16 students. Curriculum development will be completed during year one and implementation will occur years two through five. Additional outreach will occur through a research opportunity for students at IRSC and Cornell. Teams of students will work with faculty, scientists and post-docs to prepare a research proposal that uses the Agrobacterium model to design a â¿¿biofactoryâ¿Â