Grant Information

DEVELOP A NOVEL TARGET-BASED ANTI-VIRULENCE STRATEGY FOR CONTROLLING CITRUS HUANGLONGBING (HLB)

Sponsoring Institution Agricultural Research Service/USDA
Status ACTIVE
Funding Source USDA INHOUSE
Reporting Frequency Annual
Project Director LIN H
Accession Number 430046
Project Number 2034-22000-012-08R
Dates 2015-10-01 - 2018-03-31
Recipient Organization AGRICULTURAL RESEARCH SERVICE

PARLIER,CA 93648
Keywords antimicrobial
citrus
huanglongbing
pathogenicity
virulence
Research Effort Applied (30%)
Basic (60%)
Developmental (10%)
Classification Parameters
Knowledge AreaSubject of InvestigationField of SciencePercent
212 - Pathogens and Nematodes Affecting Plants 999 - Citrus, general/other 1040 - Molecular biology 100%
Goals / Objectives
  1. To identify potential virulence genes responsible for citrus HLB.
  2. To functionally validate key virulence genes.
  3. To screen antimicrobial compounds and evaluate the effect of these chemicals on target genes through in vitro and in vivo experiments.
Methods (unparsed)

We will take multiple approaches, including biochemistry, phytopathology and physiology, genetics and systems biology, to understand the mechanistic basis of citrus-HLB. We will design a high-throughput anti-microbial screening system to characterize the effect of anti-microbial molecules and develop practical control method for HLB management.

Methods
We will take multiple approaches, including biochemistry, phytopathology and physiology, genetics and systems biology, to understand the mechanistic basis of citrus-HLB. We will design a high-throughput anti-microbial screening system to characterize the effect of anti-microbial molecules and develop practical control method for HLB management.